Table 1.
Univariable Associations between Patient Demographics, Preoperative Comorbidities, and Treatment Variables and Enlargement of the TEP (n=194)
|
Total Pts No. (%) |
Enlarged TEP No. (%) |
Unadjusted RR (95% CI) |
Trend
P |
|
|---|---|---|---|---|
| Sex | ||||
| Male | 162 (83.5) | 28 (17.3) | ||
| Female | 32 (16.5) | 8 (25.0) | 1.4 (0.7-2.9) | -- |
| Race/Ethnicity | ||||
| White | 151 (18.5) | 28 (18.5) | ||
| Hispanic | 21 (10.8) | 4 (19.1) | 1.0 (0.4-2.6) | |
| Black | 15 (7.7) | 3 (20.0) | 1.1 (0.4-3.1) | -- |
| Smoking | ||||
| Never | 24 (12.4) | 2 (8.3) | ||
| Former | 77 (40.0) | 15 (19.5) | 2.3 (0.6-9.5) | |
| Current | 93 (47.9) | 19 (20.4) | 2.5 (0.6-9.8) | 0.325 |
| Alcohol | ||||
| Never | 47 (24.2) | 8 (17.0) | ||
| Former | 54 (27.8) | 11 (20.4) | 1.2 (0.5-2.7) | |
| Current | 93 (47.9) | 17 (18.3) | 1.1 (0.5-2.3) | -- |
| Pre-TL BMI | ||||
| Healthy | 76 (39.2) | 16 (21.1) | ||
| Underweight | 12 (6.2) | 4 (33.3) | 1.6 (0.6-3.9) | |
| Overweight | 69 (35.6) | 11 (15.9) | 0.8 (0.4-1.5) | |
| Obese | 35 (18.0) | 3 (8.6) | 0.4 (0.1-1.3) | 0.040 |
| Pre-TL albumin | ||||
| Normal range | 136 (70.1) | 23 (16.9) | ||
| 2.1-2.7 g/dL | 11 (5.7) | 3 (27.3) | 1.6 (0.6-4.5) | |
| <2.1 g/dL | 8 (4.1) | 3 (37.5) | 2.2 (0.8-5.8) | 0.484 |
| TSH | ||||
| Normal range | 126 (65.0) | 26 (20.6) | ||
| Low | 11 (5.7) | 2 (18.2) | 0.7 (0.2-2.1) | |
| High | 21 (10.8) | 3 (14.3) | 0.9 (0.2-3.2) | -- |
| ACE-27 comorbidity | ||||
| None/mild | 129 (66.5) | 22 (17.1) | ||
| Moderate/severe | 65 (33.5) | 14 (21.5) | 1.3 (0.7-2.3) | |
| Tumor site | -- | |||
| Glottic/subglottic | 102 (52.6) | 14 (13.7) | ||
| Supraglottic | 56 (28.9) | 11 (19.6) | 1.4 (0.7-2.9) | |
| Hypopharynx | 21 (10.8) | 7 (33.3) | 2.4 (1.1-5.3) | |
| Other | 15 (7.7) | 4 (26.7) | 1.9 (0.7-5.1) | 0.037 |
| T classification | ||||
| T2 | 9 (4.6) | 2 (22.2) | ||
| T3 | 19 (9.8) | 3 (15.8) | 0.7 (0.1-3.5) | |
| T4 | 57 (29.4) | 13 (22.8) | 1.0 (0.3-3.8) | |
| Recurrent | 104 (53.6) | 18 (17.3) | 0.8 (0.2-2.8) | -- |
| N classification | ||||
| N0 | 41 (21.1) | 3 (7.3) | ||
| N1 | 12 (6.2) | 3 (25.0) | 3.4 (0.8-14.8) | |
| N2 or N3 | 34 (17.5) | 12 (37.5) | 4.8 (1.5-15.7) | |
| Recurrent | 104 (53.6) | 18 (17.3) | 2.4 (0.7-7.6) | 0.005 |
| Prior radiation | ||||
| No | 80 (41.2) | 17 (21.3) | ||
| Yes | 114 (58.8) | 19 (16.7) | 0.8 (0.4-1.4) | |
| Prior chemo | ||||
| No | 153 (78.9) | 32 (20.9) | ||
| Yes | 37 (19.1) | 4 (9.8) | 0.5 (0.2-1.2) | |
| Extent surgery | ||||
| TL | 147 (75.8) | 24 (16.3) | ||
| TL + PP | 26 (13.4) | 5 (19.2) | 1.2 (0.5-2.8) | |
| TLP | 21 (10.8) | 7 (33.3) | 2.0 (1.0-4.1) |
Non-significant associations with age, marital status, financial status, diabetes, type of radiotherapy, >1 course preoperative radiotherapy, and laryngeal dysfunction necessitating laryngectomy are not shown