Table 3. Averages of estimated pK_a Values, Standard Deviations, and Absolute Errors of the Blocked Aspartic Acid from 18 EDS-HREX Constant pH Simulations by 1 ns Time Window Along 5 ns Trajectories.

time (ns)	pKa	std. dev.
0–1	3.92	0.094
0–2	3.90	0.032
0–3	3.89	0.022
0–4	3.93	0.014
0–5	3.94	0.046