Relaxivity of HSA-bound Gd(5b)
(filled circles) and Gd(4b) (open circles) at pH 7.4,
at (A) 10 °C, (B) 25 °C, (C) 37 °C, and (D) 50 °C.
The difference between the solid and open circles is the inner-sphere
contribution to the Gd(4b) relaxivity, and the solid
line is the fit to the data described in the text.