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. Author manuscript; available in PMC: 2014 Nov 14.
Published in final edited form as: Sci Transl Med. 2014 May 14;6(236):236ra63. doi: 10.1126/scitranslmed.3008104

Figure 4. PGT121 can utilize glycans in the V1/V2 loops to neutralize isolates when the glycan site at N332 or N334 is removed by alanine mutagenesis.

Figure 4

(A) Neutralization potency of PGT121 was measured on 92BR020, 92RW020 and CAP45 glycan mutant viruses for which N-linked glycosylation sites have been removed singly (solid line) or in combination with N332 (dashed line) by alanine mutagenesis. PGV04 was included as a control. (B) Neutralization potency of PGT121-123 was measured on virus isolate 92BR020 N332A mutant virus (red) made in HEK 293T cells (solid line) and a GnT1−/− deficient HEK 293S cell line (dotted line) and the potency compared to WT virus (black).

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