Figure 6. bnMAbs to the high-mannose patch can utilize alternate glycan sites to neutralize viruses that naturally do not have a glycan site present at the N332/334 position.
(A) PGT121, (B) PGT123, and (C) PGT124 were tested for neutralization of ZM53 glycan site mutants. (D) PGT125, (E) PGT127, and (F) PGT128 were tested for neutralization of BG505 glycan site mutants. Mutants were generated by site-directed mutagenesis.