Fig. 2.

a Receiver-operating characteristic (ROC) curve and area under the curve (AUC) for neutrophil gelatinase lipocalin (NGAL), FGF-2, EGF, and all three biomarkers combined, demonstrate the predictive ability of each biomarker profile to detect acute kidney injury (AKI) in critically ill children admitted to the ICU with sepsis or requiring extracorporeal membrane oxygenation (ECMO). b Bar graph showing the results of a contingency table analysis combining urinary cut-off values of (NGAL) (548 ng/mg) and FGF-2 (15.55 pg/mg). A total of 58 control urine samples were collected from healthy controls (n=21), critically ill children without AKI (n=20), and critically ill children without AKI at illness resolution (n=17). A total of 19 urine samples were collected from critically ill children with AKI. c Bar graph showing the results of a contingency table analysis combining the urinary cut-off values of NGAL (548 ng/mg), FGF-2 (15.55 pg/mg), and EGF (31,598 pg/mg). A total of 58 control urine samples and 19 AKI urine samples were collected from the patients described above. All cut-off values are expressed as a ratio of the urinary creatinine (UCr)