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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 May 14;24(14):3113–3117. doi: 10.1016/j.bmcl.2014.05.009

Figure 3.

Figure 3

A) Crystal structure of compound 3e (see Supporting Information, CCDC deposit number 978337). Hydrogen atoms are not shown. The dihedral twist angle between the imidazole and dimethylaniline rings is indicated. B) Model of the compound 3e crystal structure (light blue) superimposed on the HCV translation inhibitor 1 (yellow) in the subdomain IIa RNA co-crystal structure.17 Hydrogen bonds and nucleotides participating in intramolecular contacts are indicated. Residues G52 and A53, which stack below and above the ligand are shown transparent.