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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 May 14;24(14):3113–3117. doi: 10.1016/j.bmcl.2014.05.009

Table 1.

Activity of 1-aryl-benzimidazole derivatives 3, 4 and 5 in the FRET assay.

Compound R1 R2 R3 EC50 [μM]a
3a 5-OH H H n.a.
3b/5b graphic file with name nihms598000t1.jpg H H 250 ± 66
3c/5c graphic file with name nihms598000t2.jpg H H 210 ± 39
3d graphic file with name nihms598000t3.jpg H H n.a.
3e graphic file with name nihms598000t4.jpg graphic file with name nihms598000t5.jpg H 95 ± 6
3f/5f graphic file with name nihms598000t6.jpg graphic file with name nihms598000t7.jpg H 170 ± 16
3g graphic file with name nihms598000t8.jpg graphic file with name nihms598000t9.jpg H 120 ± 5
3h graphic file with name nihms598000t10.jpg graphic file with name nihms598000t11.jpg H 74 ± 2
3i graphic file with name nihms598000t12.jpg graphic file with name nihms598000t13.jpg H 100 ± 12
4ba graphic file with name nihms598000t14.jpg H CH3 100 ± 13
4ca graphic file with name nihms598000t15.jpg H CH3 > 500
4ab 5-OH H C6H5 n.a.
4bb graphic file with name nihms598000t16.jpg H C6H5 > 500
4cb graphic file with name nihms598000t17.jpg H C6H5 > 500
4eb graphic file with name nihms598000t18.jpg graphic file with name nihms598000t19.jpg C6H5 precip.
4fb graphic file with name nihms598000t20.jpg graphic file with name nihms598000t21.jpg C6H5 precip.
a

EC50 values (± standard error from triplicate experiments) are shown for 2-aminobenzimdiazoles 3 and acyl derivates 4. All tested 2-hydroxybenzimidazoles 5 precipitated RNA at a concentration between 50–100 μM.