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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biogerontology. 2014 Apr 26;15(4):329–337. doi: 10.1007/s10522-014-9501-8

Figure 2. Proliferative capacity on 3D collagen is highly correlated with IGF1R expression.

Figure 2

Proliferation of human dermal fibroblasts on 2D tissue culture is not correlated with IGF1R expression (R2=0.05 Figure 2a.). In contrast, proliferative activity of the same cells on a 3D collagen matrix was highly correlated with IGF1R expression (R2=0.66 Figure 2b). R2, or coefficient of determination, is a dimensionless value between 0 and 1 in which 1 is full correlation and 0 is no correlation. Cell lines from aged donors are represented by circles, cell lines from young donors are represented by squares.