Table 3.
MIC and CC50 values for compounds P10 – P15a
| Cpd # | Structures | MIC (μg/mL) | CC50 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| linker | Am | E.col+ | E.col− | P.aer | K.pne | B.sub | MRSA | VRE | B. anth | HeLa | |
| P10 |
|
|
0.63 | 0.31 | 2.5 | 0.63 | 0.08 | 0.16 | 0.16 | 0.08 | 14.3 |
| P11 |
|
|
2.5 | 0.63 | 2.5 | 1.25 | 0.24 | 0.63 | 1.25 | 0.63 | 4.6 |
| P12a |
|
|
2.80 | 0.27 | 66.7 | 60.0 | 0.16 | 0.94 | 1.56 | 1.09 | 182.2 |
| P12b | ” |
|
1.25 | 0.63 | 26.7 | 20.0 | 0.31 | 1.04 | 0.63 | 0.52 | 14.5 |
| P12c | ” |
|
0.63 | 0.31 | 10.0 | 2.5 | 0.08 | 0.31 | 0.31 | 0.16 | 8.7 |
| P12d | ” |
|
5.0 | 0.47 | 40.0 | 15.0 | 0.43 | 1.88 | 2.5 | 1.25 | 12.7 |
| P12e | ” |
|
1.25 | 0.31 | 53.3 | 2.5 | 0.16 | 0.63 | 0.63 | 0.31 | 22.5 |
| P13a |
|
|
1.25 | 0.16 | 1.25 | 1.56 | 0.08 | 0.31 | 0.39 | 0.16 | 15.6 |
| P13b | ” |
|
1.88 | 0.27 | 5.0 | 2.5 | 0.08 | 0.31 | 0.63 | 0.63 | 2.2 |
| P13c | ” |
|
80 | 0.63 | 25 | 8.8 | 3.75 | 2.5 | 5.0 | 1.09 | 16.7 |
| P13d | ” |
|
8.3 | 0.31 | 8.3 | 2.5 | 0.16 | 0.83 | 0.63 | 0.63 | 19.6 |
| P14 | See scheme 6 | 0.31 | 0.31 | 1.25 | 0.31 | 0.08 | 0.16 | 0.16 | 0.08 | 1.5 | |
| P15 | See scheme 6 | 20.0 | 10.0 | 40.0 | 20.0 | 2.5 | 5.0 | 5.0 | 2.5 | - | |
a
bacterial strains: Ecol+ = E. coli 700 TolC+, Ecol− = E. coli TolC -, P.aer = P. aeruginosa PAO 1, K. pne = K. pneumonia 13882, B. subs = B. subtilis BD54, MRSA = methicillin-resistant S. aureus 1094, VRE = vacomycin-resistant E. faecalis ATCC 51575, B. anth = B. anthracis Sterne; MIC ≤1: green; 1< MIC ≤5: blue; 5< MIC ≤20: yellow; MIC >20: pink; CC50 units in μg/mL