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. Author manuscript; available in PMC: 2014 Jul 14.
Published in final edited form as: Cell Transplant. 2012 Dec 4;23(2):153–165. doi: 10.3727/096368912X658980

Figure 3.

Figure 3

Release of high-mobility group box 1 (HMGB1), C-peptide, and proinsulin, but not soluble receptor for advanced glycation end products (sRAGE), by damaged human islets. (A) Control islets, cytokine-induced damaged islets, and hypoxia-induced damaged islets were stained with Hoechst33342 and propidium iodide (HO342/PI) (left), insulin (green), HMGB1 (red), and 4′,6-diamidino- 2-phenylindole (DAPI; blue). Scale bars: 100 μm. (B) ELISA measurements of the amount of released proinsulin, C-peptide, HMGB1, and sRAGE from the three groups of islets. The data are expressed as mean ± SD. *p < 0.05 compared to control. nd, not detected.