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. Author manuscript; available in PMC: 2014 Jul 14.
Published in final edited form as: Exp Biol Med (Maywood). 2013 May;238(5):525–538. doi: 10.1177/1535370213489446

Figure 2. Autophagy receptor complex for the degradation of protein aggregates.

Figure 2

Specific ubiquitin (ub) chains are incorporated into the protein aggregates and recruit p62 via its UBA domain, which further delivers ubiquitinated protein aggregates to autophagosomes by interacting with LC3 via its LIR domain. Ubiquitin also recruits HDAC6, which facilitates the transportation of protein aggregates to the MTOC as well as fusion of autophagosomes with lysosomes for the subsequent degradation of protein aggregates. ALFY functions as a scaffold protein for p62 positive protein aggregates that targets them for degradation by autophagy via interaction with the Atg5–Atg12 complex.