Table 1.
Patient and tumor characteristics
| Parameters |
n |
Spontaneous VDE (mm/y) |
IDH1 Mutation Status |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean ± SD | Median | Range | P | IDH1 + | IDH1− | P | |||
| Clinical parameters | |||||||||
| Sex | 131 | .592 | .477 | ||||||
| Male | 79 | 5.2 ± 4.4 | 3.7 | 0–22.6 | 79.8% | 20.2 | |||
| Female | 52 | 5.7 ± 6.8 | 3.8 | 0–31.0 | 84.6 | 15.4 | |||
| Age | 131 | .887 | .031 | ||||||
| <40 | 75 | 5.8 ± 6.4 | 3.7 | 0–31.0 | 88.0 | 12.0 | |||
| ≥40 | 56 | 4.9 ± 4.0 | 3.9 | 0–19.2 | 73.2 | 18.3 | |||
| Increased intracranial pressure | 109 | .973 | .343 | ||||||
| Yes | 2 | 11.0 ± 15.8 | 11.0 | 0–31.0 | 50.0 | 50.0 | |||
| No | 107 | 5.0 ± 5.1 | 3.6 | 0–22.0 | 80.4 | 19.6 | |||
| Neurological deficit | 109 | .271 | .180 | ||||||
| Yes | 20 | 6.5 ± 7.0 | 4.6 | 0–27.9 | 90.0 | 10.0 | |||
| No | 89 | 4.8 ± 4.9 | 3.5 | 0–31.0 | 77.5 | 22.5 | |||
| Seizures | 109 | .156 | .365 | ||||||
| Yes | 78 | 5.6 ± 5.9 | 3.1 | 0–31.0 | 82.1 | 17.9 | |||
| No | 31 | 3.8 ± 3.2 | 3.8 | 0–15.0 | 74.2 | 25.8 | |||
| KPS | 131 | .005 | .114 | ||||||
| >70% | 125 | 5.1 ± 5.3 | 3.7 | 0–31.0 | 80.8 | 19.2 | |||
| ≤70% | 6 | 11.4 ± 6.6 | 9.9 | 4.7–22.0 | 100.0 | 0 | |||
| Imaging parameters | |||||||||
| Cerebral lobes involved | 118 | .119 | .054 | ||||||
| <2 | 79 | 4.8 ± 5.3 | 3.5 | 0–31.0 | 88.6 | 11.4 | |||
| ≥2 | 39 | 6.5 ± 5.7 | 4.7 | 0–22.6 | 74.4 | 25.6 | |||
| Corpus callosum involvement | 117 | .434 | .410 | ||||||
| No | 105 | 5.0 ± 5.3 | 3.7 | 1.1–31.0 | 84.8 | 15.2 | |||
| Yes | 12 | 7.6 ± 7.0 | 6.8 | 0–22.6 | 75.0 | 25.0 | |||
| Tumor location | 131 | .666 | .509 | ||||||
| Frontal | 62 | 5.2 ± 5.9 | 3.4 | 0–31.0 | 80.7 | 19.4 | |||
| Temporal | 22 | 6.7 ± 7.1 | 3.9 | 0–28.0 | 77.3 | 22.7 | |||
| Insular | 31 | 5.0 ± 3.5 | 4.7 | 0.4–14.2 | 80.7 | 19.3 | |||
| Parietal | 16 | 5.1 ± 4.1 | 3.7 | 0.6–16.9 | 93.8 | 6.2 | |||
| Contrast enhancement | 131 | .582 | .449 | ||||||
| No | 121 | 5.2 ± 5.0 | 3.8 | 0–31.0 | 81.0 | 19.0 | |||
| Yes | 10 | 7.5 ± 9.9 | 2.4 | 0–27.9 | 90.0 | 10.0 | |||
| Tumor volume | 131 | .778 | .589 | ||||||
| <100 cc | 104 | 5.2 ± 5.3 | 5.8 | 0–31.0 | 80.8 | 19.2 | |||
| ≥100 cc | 27 | 6.4 ± 6.1 | 3.6 | 0–22.6 | 85.2 | 14.8 | |||
| Spontaneous VDE | 131 | .898 | |||||||
| <8 mm/y | 108 | 81.5 | 18.5 | ||||||
| ≥8 mm/y | 23 | 82.6 | 17.4 | ||||||
| Histopathological and molecular parameters | |||||||||
| Histopathological diagnosis | 131 | .536 | .087 | ||||||
| Astrocytoma | 25 | 5.5 ± 5.5 | 4.0 | 0.4–27.9 | 72.0 | 28.0 | |||
| Oligodendroglioma | 71 | 5.3 ± 5.8 | 3.7 | 0–31.0 | 88.6 | 11.4 | |||
| Mixed glioma | 35 | 5.6 ± 4.9 | 4.6 | 0–22.9 | 75.0 | 25.0 | |||
| Oligodendroglial component | 131 | .526 | .222 | ||||||
| Yes | 106 | 5.4 ± 5.5 | 3.7 | 0–31.0 | 83.8 | 18.2 | |||
| No | 25 | 5.5 ± 5.5 | 4.0 | 0.4–27.9 | 72.0 | 28.0 | |||
| Proliferation rates | 115 | .888 | .914 | ||||||
| <5% | 70 | 5.4 ± 5.9 | 3.5 | 0–31.0 | 81.4 | 18.6 | |||
| ≥5% | 45 | 5.1 ± 4.7 | 3.7 | 0–22.0 | 82.2 | 17.8 | |||
| 1p19q Codeletion | 119 | .077 | .497 | ||||||
| Yes | 38 | 5.0 ± 6.0 | 3.1 | 0–31.0 | 79.0 | 20.1 | |||
| No | 81 | 5.6 ± 5.0 | 4.4 | 0–27.9 | 84.2 | 15.8 | |||
| p53 Overexpression | 125 | .202 | .250 | ||||||
| Yes | 65 | 5.8 ± 5.2 | 4.4 | 0–27.9 | 86.2 | 13.8 | |||
| No | 60 | 5.0 ± 5.6 | 3.5 | 0–31.0 | 78.3 | 21.7 | |||
| IDH1 mutation | 131 | .823 | |||||||
| Yes | 107 | 5.4 ± 5.6 | 3.8 | 0–31.0 | |||||
| No | 24 | 5.2 ± 5.0 | 3.8 | 0–19.2 | |||||
| First-line oncological treatments | |||||||||
| Surgical resection | 131 | .236 | .574 | ||||||
| Yes | 83 | 4.5 ± 4.2 | 3.6 | 0–31.0 | 83.1 | 16.9 | |||
| No | 48 | 6.8 ± 6.9 | 4.0 | 0.5–27.9 | 79.2 | 20.8 | |||
| Extent of surgical resection | 131 | .396 | .339 | ||||||
| Biopsy | 48 | 6.9 ± 7.7 | 4.0 | 0.5–27.9 | 79.2 | 20.8 | |||
| Partial removal | 16 | 4.4 ± 3.2 | 3.7 | 0–12.3 | 87.5 | 12.5 | |||
| Subtotal removal | 49 | 4.5 ± 3.1 | 4.0 | 0–15.0 | 83.7 | 16.3 | |||
| Total removal | 18 | 4.8 ± 7.1 | 3.2 | 0–31.0 | 77.8 | 22.2 | |||
| Radiation therapy | 131 | .467 | .158 | ||||||
| Yes | 23 | 6.7 ± 5.8 | 4.5 | 0.6–22.6 | 91.3 | 8.7 | |||
| No | 108 | 5.1 ± 5.4 | 3.6 | 0–31.0 | 79.6 | 20.4 | |||
| Chemotherapy | 131 | .040 | .099 | ||||||
| Yes | 14 | 3.7 ± 4.6 | 2.6 | 0.4–19.2 | 64.3 | 35.7 | |||
| No | 117 | 5.6 ± 5.5 | 4.0 | 0–31.0 | 83.8 | 16.2 | |||
Boldface indicates statistically significant.