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. Author manuscript; available in PMC: 2014 Jul 14.
Published in final edited form as: Ann Neurol. 2010 Nov 23;69(3):509–520. doi: 10.1002/ana.22162

FIGURE 5.

FIGURE 5

Oral N-acetylcysteine restores reactive thiol content of SNc dopaminergic neurons in EAAC1−/− mice. (A) Representative confocal sections through mouse SNc labeled with C5-maleimide (green) to label reactive thiols and immunostained for tyrosine hydroxylase (red) to identify dopaminergic neurons. Bar = 50µm. (B) Quantification of C5-maeimide fluorescence in TH-positive neurons indicates that reactive thiol content of dopaminergic neurons is lower in EAAC1−/− mice than in WT mice, but normalized in EAAC1−/− mice treated with oral NAC. *p < 0.05; n = 4.