Skip to main content
. Author manuscript; available in PMC: 2014 Jul 14.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Nov 7;34(1):26–33. doi: 10.1161/ATVBAHA.113.302355

Figure 5.

Figure 5

Adenoviral vectors encoding G5G8 (AdG5G8)-dependent increase in plasma cholesterol is blocked by ezetimibe. A and B, Lean and obese db/db mice were administered control and AdG5G8 vectors. C and E, C57Bl6/J mice were administered the control vector or AdG5G8 in the absence or presence of ezetimibe (AdG5G8+ezetimibe [EZ]). Cholesterol in total (A and C) and fast protein liquid chromatography (FPLC)-fractionated (B and D) serum was determined by enzymatic colorimetric assay. E, FPLC fraction of 8 samples (peak cholesterol) from 3 mice in each group was pooled and analyzed by immunoblotting for apolipoprotein B (ApoB). HDL indicates high-density lipo-protein; and LDL, low-density lipoprotein.