TABLE 4.
Overall Survival in Pediatric Patients With Invasive Melanoma
| Factor | Dead/No. | 5-Years OS, % | 10-Year OS, % |
|---|---|---|---|
| Overall | 31/365 | 88.9 | 80.6 |
| Age, y (P = .1473, log-rank test) | |||
| ≤5 | 0/6 | 100.0 | 100.0 |
| >5 to ≤10 | 0/19 | 100.0 | 100.0 |
| >10, to ≤15 | 11/98 | 81.4 | 69.7 |
| >15 to ≤20 | 20/222 | 88.9 | 79.5 |
| >20 to ≤21 | 0/20 | 100.0 | 100.0 |
| Sex (P = .9568, log-rank test) | |||
| Female | 16/210 | 89.2 | 80.8 |
| Male | 15/155 | 80.4 | 80.4 |
| Thickness, mm (P = .0077, log-rank test) | |||
| 0-1.0 | 2/147 | 97.0 | 97.0 |
| 1.01-2.0 | 9/84 | 87.2 | 70.1 |
| 2.01-4.0 | 6/71 | 84.1 | 77.6 |
| >4.0 | 4/25 | 80.1 | 80.1 |
| Ulceration (P = .0022, log-rank test) | |||
| No | 12/258 | 91.6 | 86.7 |
| Yes | 6/35 | 74.1 | 59.3 |
| Unknown | 3/34 | 91.9 | 76.6 |
| Mitoses (P = .1637, log-rank test) | |||
| No | 6/122 | 91.6 | 88.3 |
| Yes | 9/112 | 83.4 | 76.9 |
| Unknown | 16/131 | 90.2 | 77.6 |
| Lymph node status (P = .0170, log-rank test) | |||
| Observation | 9/121 | 90.8 | 84.6 |
| No SLNB, LND+ | 9/30 | 63.1 | 63.1 |
| SLNB− | 3/126 | 97.8 | 80.7 |
| SLNB+, no LND | 0/5 | 100.0 | NA |
| SLNB+, LND− | 2/31 | 76.0 | NA |
| SLNB+, LND+ | 1/18 | 88.9 | NA |
| Stage (AJCC 6th edition) (P<.0001, log-rank test) | |||
| I | 3/174 | 96.7 | 94.1 |
| II | 6/67 | 88.0 | 79.6 |
| III | 7/75 | 84.2 | 77.1 |
| IV | 4/8 | 40.0 | NA |
Abbreviations: +, positive; −, negative; AJCC, American Joint Committee on Cancer; LND, lymph node dissection; NA, not applicable; OS, overall survival; SLNB, sentinel lymph node biopsy.