Table 1. PV-specific and control iPSC lines used in this study.

iPSC clone	Donor	JAK2 WT allele	JAK2 V617F allele
BC1	Healthy donor	2	0
TNC1	Sickle cell anemia	2	0
iPV183	PV patient #1	1	1
PVB1.11	PV patient #2	2	0
PVB1.15		2	0
PVB1.4		0	2
PVB1.18		0	2

A panel of iPSCs derived from healthy donors and PV patients were used for this study. In addition to a healthy donor- and a sickle cell anemia patient-derived iPSCs, two clones generated from a PV patient’s blood cells also contained only wild-type JAK2 alleles (WT/WT). iPSC clones with homozygous JAK2 V617F mutation (V617F/V617F) were derived from the same PV patient. iPSCs with heterozygous JAK2 (WT/V617F) were derived from a separate PV patient in a previous study [33].

Abbreviations: iPSC, induced pluripotent stem cell; PV, polycythemia vera.