Table 3.
Gene ontology analysis of differentially methylated CpG sites in monocytes from Behçet’s disease patients compared to healthy controls
| Category | Description | Genes | P Value | FDR (%) |
|---|---|---|---|---|
|
Monocytes | ||||
| MF:0008092 | Cytoskeletal protein binding | OBSCN, MYH15, SSH1, MYO1C, FSCN2, BAIAP2L1, BAIAP2, MYO1D, RPH3AL, SYNPO2, HOMER2, TNNI2, MPRIP, KIF1B, ANK1 | 0.0024 | 3.37 |
| CC:0015629 | Actin Cytoskeleton | MYH15, FSCN2, MYO1C, MYO1D, FERMT1, SYNPO2, SLC9A3R1, BMF, FILIP1L, TNNI2 | 0.0037 | 4.75 |
| CC:0031430 | M band | OBSCN, ANK1, ENO1 | 0.0044 | 5.59 |
| CC:0016459 | Myosin Complex | MYH15, MYO1C, MYO1D, BMF, FILIP1L | 0.0064 | 8.04 |
| CC:0030016 | Myofibril | HDAC4, OBSCN, ANK1, MYH15, TNNI2, ENO1 | 0.0088 | 10.87 |
| MF:0008093 | Cytoskeletal adaptor activity | ANK1, BAIAP2L1, BAIAP2 | 0.0097 | 12.92 |
| CC:0005737 | Cytoplasm | TGOLN2, MYH15, CHMP6, C16ORF70, MIPEP, CUL3, NLRC4, ANK1, EDARADD, BSG, BCL2L14, BAIAP2, HAL, PDE4D, RPTOR, NPC1, ATP2C1, TRIM34, PCMTD1, FILIP1L, ANKFY1, MCTS1, TRIM39, SH3GL1, SSH1, PFKFB3, GNE, CLU, CALR, AZI1, SCRIB, ADAP1, JRK, ARG1, LPCAT1, GALNS, DHODH, RNF11, DYRK4, GLO1, TRAF6, BMF, TEC, B4GALT5, PTPN7, OBSCN, UAP1, ABR, MYO1C, NXF2, RPS9, SULT6B1, HOMER2, MPRIP, TNNI2, HDAC4, LASS3, HIVEP3, COPS2, MAD1L1, FERMT1, IL4I1, CD93, CHST12, TRIM6, CHST15, ACAD8, GOLGA3, PIGY, RPH3AL, ARHGAP24, PRKCB, EML4, EIF4G1, KIF1B, HIPK3, LRMP, GNAS, PCYOX1, TRIM6-TRIM34, SEC14L1, STK40, DAPP1, CCS, ETV6, PCSK6, EXOC2, ENO1, FAM125B, NXF2B, SYNPO2, PARK2, STAB2, CSGALNACT1, MRPL21, RPS6KA2, TRPC4AP, CYP4F3, RAB38, SLC15A4, VPS28, ACSM5, CBS | 0.011 | 13.81 |
| CC:0043292 | Contractile fiber | HDAC4, OBSCN, ANK1, MYH15, TNNI2, ENO1 | 0.012 | 15.07 |
| CC:0005856 | Cytoskeleton | MAD1L1, MYH15, SSH1, GNE, DNAH3, FERMT1, AZI1, ANK1, BMF, DLG2, FSCN2, MYO1C, MYO1D, NXF2B, NXF2, SYNPO2, PDE4D, SLC9A3R1, ARHGAP24, HOMER2, RGS14, TNNI2, MPRIP, EML4, KIF1B, TBCD, FILIP1L | 0.014 | 16.44 |
| CC:0031672 | A band | OBSCN, ANK1, ENO1 | 0.014 | 16.72 |
| BP:0009225 | Nucleotide-sugar metabolic process | CSGALNACT1, UAP1, GNE | 0.012 | 18.04 |
| CC:0005802 | Trans-Golgi network k | TGOLN2, ATP2C1, C16ORF70, GNAS | 0.015 | 18.32 |
| MF:0003779 | Actin binding | MYH15, SSH1, FSCN2, MYO1C, BAIAP2L1, MYO1D, SYNPO2, HOMER2, TNNI2, MPRIP | 0.015 | 18.75 |
| CC:0012505 | Endomembrane system | MAD1L1, BSG, BCL2L14, PIGY, MYO1C, CHMP6, C16ORF70, RPH3AL, CSGALNACT1, NPC1, KIF1B, ATP2C1, CHST12, LRMP, GNAS, CYP4F3, GOLGA3 | 0.017 | 19.91 |