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. Author manuscript; available in PMC: 2014 Jul 14.
Published in final edited form as: Cell Rep. 2014 Feb 13;6(4):633–645. doi: 10.1016/j.celrep.2014.01.027

Figure 6. SRC-2 Deletion Significantly Disrupts the Cell-Autonomous Clock.

Figure 6

(A) qPCR analysis of circadian gene expression in synchronized MEFs isolated from SRC-2flox/flox mice infected with either Ad-GFP or Ad-Cre-GFP. Data represent triplicates at each time point for maximal gene expression of Ad-GFP normalized to one, graphed as the mean ± SEM. *p < 0.05 versus WT.

(B) Heatmap of metabolic phenotype microarray of carbon metabolism in synchronized MEFs isolated from SRC-2flox/flox mice infected with either Ad-GFP or Ad-Cre-GFP at Hr10 (n = 3). Data are graphed as the mean ± SEM. *p < 0.05 versus WT mice.

(C) Schematic representation of the role of SRC-2 as a BMAL1:CLOCK transcriptional coactivator for core clock genes.