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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Matrix Biol. 2013 Sep 28;34:96–104. doi: 10.1016/j.matbio.2013.09.005

Figure 4. Tendon and muscle mRNA expression of IGF-I.

Figure 4

The figure shows IGF-IEa mRNA levels in Achilles tendon (A) and IGF-I isoforms (IEa, IEb and IEc) and IGF-IR mRNA levels in calf muscle (B). Mice with low GH/IGF-I activity (GHR−/−, grey bars, tendon: n=8, muscle: n=15) or high GH/IGF-I activity (bGH, black bars, tendon: n=7, muscle: n=14) are shown relative to control mice (CTRL, only error bars visible, tendon: n=12, muscle: n=24). All data are relative to GAPDH mRNA. IGF-IR = IGF-I receptor. Values are geometric mean ± back-transformed SEM (**p<0.01; ***p<0.001, only differences compared to control are shown).