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. Author manuscript; available in PMC: 2014 Jul 14.
Published in final edited form as: Oncogene. 2013 Jul 15;33(24):3172–3182. doi: 10.1038/onc.2013.279

Figure 5.

Figure 5

Non-degradable Slug increases in vivo cancer metastasis of lung adenocarcinoma cells. (a) Effects of Slug overexpression on metastasis in vivo. Upper panel: representative lungs of mice i.v. injected with CL1-5/control, CL1-5/wtSlug, or CL1-5/4SA cells. Lower panel: Histological examination of the lungs by hematoxylin-eosin staining. (b) Quantitative evaluation of lung metastatic nodules 4 weeks after tail-vein injection. Data are expressed as the mean±s.e.m. (n=8 per group). (c) The survival curve (lower panel) of the mice i.v. injected with CL1-5/control (n=8), CL1-5/wtSlug (n=8), or CL1-5/4SA cells (n=8). The number of death/total in each group at 35 days post i.v. injection is presented in the upper panel. Data are expressed as the mean±s.d. *P < 0.05 by the log-rank (Mantel-Cox) test.