Table 4. Significant associations.
Disease | SNP ID | Chr | Region (Mb) | Gene | BF2 | P2 | BF1 | P1 |
---|---|---|---|---|---|---|---|---|
CAD | rs7104543 | 11 | 120.16–120.24 | GRIK4 | 7.29 | 10.74 | 0.71 | 2.36 |
RA | rs1010342 | 4 | 1.04–1.08 | SPON2 | 6.11 | 11.98 | 0.60 | 2.33 |
RA | rs11218032 | 11 | 120.16–120.24 | GRIK4 | 11.60 | 14.50 | −0.90 | 0.52 |
T2D | rs2383208 | 9 | 22.12–22.13 | CDKN2A, CDKN2B | 7.62 | 8.57 | 1.96 | 3.69 |
CD | rs9268858 | 6 | 32.54–32.56 | HLA-DRA | 5.20 | 8.27 | 1.66 | 3.35 |
RA | rs1605705 | 3 | 7.24–7.28 | GRM7 | 5.76 | 8.43 | 1.04 | 2.82 |
T1D | rs6578246 | 11 | 2.18–2.26 | INS-IGF2 | 4.96 | 8.52 | 2.34 | 4.09 |
T1D | rs3218256 | 22 | 35.87–35.87 | IL2RB | 4.60 | 6.47 | 2.44 | 4.26 |
P2 = −log10 P-value, which is the minimum P-value over 10 independent EM runs, and in each EM run a P-value was computed using logistic regression Equation 8. BF2 = log10 Bayes factor, which is averaged over 10 independent EM runs, and in each EM run a Bayes factor was computed using our haplotype method. P1 and BF1 are P-values and Bayes factors for the single-SNP test, respectively. The coordinates are from NCBI Build 35.