Figure 2.

One congenic and 13 subcongenic chromosomes generated through breeding. (A) Location of SNPs polymorphic between the B6 (red) and non-B6 (blue) strains used to identify the original congenic region are shown next to a representation of mouse chromosome 11. The non-B6 markers are polymorphic between B6 and 129 and chosen because of the previous hypothesis that the protection was derived from the 129 strain. Two regions, one located at 30 Mb and the other located at 110 Mb, were not identified by the 2008 SNP scan (asterisk). (B) Thirteen different subcongenic configurations of chromosome 11 (Chr11-1 through Chr11-13), with varying degrees of non-B6 DNA, were created by backcrossing the B6.POSA- Y^POS with B6-XX females. Region 110 is circled.