Figure 4.

Genotype–phenotype correlation show that heterozygous and homozygous presence of Chr11-13, which has only the 110 region of non-B6 origin, provides significant protection from B6-Y^POS sex reversal in adult and embryonic gonads. (A) B6-Y^POS adult animals, none of the animals are Y^POS males with testes. For adult animals that are heterozygous or homozygous for Chr11-13, there is significantly increased protection from B6-Y^POS sex reversal. (B) In B6-Y^POS animals, the majority of gonads in XY^POS animals are Ot (>50% ovary) or complete ovary. Embryonic gonad analysis showed that all LineB6/11-13 and Line11-13/Line11-13 gonads have some degree of testicular cord development and that none are XY^POS ovaries. *Fisher exact P-value < 0.001 for the three-way comparison.