Table 3.
Clinical, and CMR data in controls and in asymptomatic versus symptomatic Duchenne carriers
|
Variables |
Controls |
Asymptomatic |
Symptomatic |
F |
p< |
|---|---|---|---|---|---|
| (n = 37) | (n = 21) | (n = 9) | |||
|
Demographic, clinical |
|
|
|
|
|
| Age (months) |
418 ± 22 |
441 ± 29 |
501 ± 44 |
1.4 |
0.25 |
| Body surface area (m2) |
1.68 ± 0.02 |
1.65 ± 0.03 |
1.63 ± 0.04 |
0.8 |
0.44 |
| Heart rate (b/min) |
78 ± 1 |
75 ± 1 |
80 ± 2 |
2.5 |
0.09 |
|
CMR |
|
|
|
|
|
| Left ventricle (LV) |
|
|
|
|
|
| Ejection fraction (%) |
65 ± 1 |
63 ± 1 |
61 ± 2 |
2.0 |
0.14 |
| End-diastolic volume (ml/m2) |
106 ± 3 |
112 ± 4 |
109 ± 5 |
0.8 |
0.47 |
| End-systolic volume (ml/m2) |
37 ± 1 |
42 ± 2 |
42 ± 3 |
1.9 |
0.15 |
| Mass (g) |
108 ± 3 |
97 ± 4 |
93 ± 6(*) |
4.3 |
0.02 |
| Right ventricle(RV) |
|
|
|
|
|
| Ejection fraction (%) |
60 ± 1 |
60 ± 1 |
61 ± 2 |
0.2 |
0.83 |
| End-diastolic volume (ml/m2) |
100 ± 3 |
108 ± 4 |
98 ± 6 |
1.4 |
0.27 |
| End-systolic volume (ml/m2) | 40 ± 2 | 43 ± 2 | 39 ± 3 | 0.9 | 0.42 |
DMDc = Duchenne muscular dystrophy carriers. Data are corrected by BSA and mean ± standard errors.