Table 2. Summary of precuneus protein levels by clinical diagnosis category.
| NCI (N=23) |
MCI (N=21) |
AD (N=18) |
p-valuea | Pair-wise comparison | |
|---|---|---|---|---|---|
| proNGF | 0.30 ± 0.07b (0.15-0.44)c |
0.34 ± 0.08 (0.15-0.51) |
0.39 ± 0.09 (0.28-0.66) |
0.003 | NCI < AD |
| TrkA | 0.23±0.09; (0.12-0.50) |
0.19±0.09 (0.07-0.39) |
0.21±0.07 (0.09-0.35) |
0.2 | -- |
| p75NTR | 0.53 ± 0.14 (0.21-0.85) |
0.49 ± 0.17 (0.26-0.86) |
0.52 ± 0.12 (0.31-0.77) |
0.5 | -- |
| sortilin | 1.06 ± 0.40 (0.46-2.06) |
1.18 ± 0.43 (0.58-2.10) |
1.14 ± 0.43 (0.55-1.89) |
0.7 | -- |
| Erk | 0.51 ± 0.20 (0.13-0.91) |
0.46 ± 0.17 (0.28-1.03) |
0.48 ± 0.20 (0.20-0.93) |
0.6 | -- |
| p-Erk | 0.62 ± 0.22 (0.21-1.25) |
0.70 ± 0.39 (0.22-1.73) |
0.69 ± 0.34 (0.35-1.69) |
0.9 | -- |
| p-Erk/Erk ratio | 1.50 ± 1.02 (0.30-4.45) |
1.60 ± 0.91 (0.66-4.62) |
1.85 ± 1.59 (0.48-7.00) |
0.7 | -- |
| JNK | 0.43 ± 0.19 (0.18-0.82) |
0.37 ±0.07 (0.21-0.57) |
0.36 ± 0.13 (0.19-0.63) |
0.5 | -- |
| p-JNK | 0.13 ± 0.07 (0.04-0.38) |
0.16 ± 0.06 (0.06-0.25) |
0.24 ± 0.14 (0.06-0.56) |
0.015 | NCI < AD |
| p-JNK/JNK ratio | 0.34 ± 0.17 (0.15-0.90) |
0.45 ± 0.15 (0.19-0.74) |
0.67 ± 0.32 (0.19-1.29) |
<0.001 | NCI < (MCI, AD) |
| Bcl-2 | 0.41 ± 0.10 (0.15-0.58) |
0.46 ± 0.09 (0.30-0.68) |
0.52 ± 0.17 (0.29-1.02) |
0.043 | NCI < AD |
a
Kruskal-Wallis test, with Dunn's correction for multiple comparisons.
b
Mean ± standard deviation.
c
(Range).