Table 2.
Metabolic parameters in CC responsive and non-responsive patients with polycystic ovary syndrome
| CC responders (n = 38) | CC non-responders (n = 24) | P value | |
|---|---|---|---|
|
No. of patients with dyslipidemia (%) |
6 (16) |
11 (38) |
0.02 |
|
Triglycerides (mg/dl) |
90.4 ± 44.9 |
117.1 ± 67.6 |
0.08 |
|
LDL cholesterol (mg/dl) |
112.2 ± 44.6 |
116.0 ± 32.9 |
0.73 |
|
HDL cholesterol (mg/dl) |
65.3 ± 13.5 |
60.1 ± 15.6 |
0.18 |
|
Total cholesterol (mg/dl) |
192.0 ± 42.0 |
197.9 ± 31.6 |
0.57 |
|
No. of patients with IGT or DM (%) |
4 (11) |
11 (46) |
0.004 |
|
75-g OGTT |
|
|
|
|
Plasma glucose (mg/dl) |
|
|
|
|
Fasting |
88.9 ± 8.4 |
89.6 ± 7.5 |
0.76 |
|
60 min |
129.0 ± 36.3 |
159.9 ± 48.4 |
0.01 |
|
120 min |
112.1 ± 21.6 |
129.7 ± 41.9 |
0.04 |
|
AUC glucose (mg × h/dl) |
936.9 ± 192.6 |
1080.9 ± 267.3 |
0.03 |
|
IRI (μU/ml) |
|
|
|
|
Fasting |
9.6 ± 7.3 |
13.7 ± 9.7 |
0.09 |
|
60 min |
67.1 ± 34.7 |
117.6 ± 90.0 |
0.007 |
|
120 min |
61.2 ± 36.5 |
110.7 ± 107.5 |
0.02 |
|
AUC IRI (μU × h/ml) |
473.3 ± 225.9 |
799.1 ± 609.1 |
0.009 |
|
HbA1c (%) |
5.4 ± 0.4 |
5.6 ± 0.4 |
0.12 |
|
HOMA-IR |
2.3 ± 1.9 |
3.4 ± 2.9 |
0.09 |
| QUICKI | 0.36 ± 0.04 | 0.34 ± 0.05 | 0.16 |
CC: clomiphene citrate, IGT: impaired glucose tolerance, DM: diabetes mellitus, AUC: area under the curve, IRI: immunoreactive insulin, HbA1c: hemoglobin A1c, HOMA-IR: homeostasis model assessment of insulin resistance, QUICKI: quantitative insulin-sensitivity check index.