Table 4. Lymphedema, osteopenia, osteoporosis and heart disease reported by invasive breast cancer cases, in comparison to women without cancer, according to time since invasive breast cancer diagnosis or reference date.
| Time Interval since Diagnosis/Reference (yrs): |
Women Under Observationa |
Yes n (%) |
No n (%) |
Missingb n |
Hazard Ratioc (95% CI)d |
|---|---|---|---|---|---|
| First Lymphedema Diagnosis by a Health Professional During Time Interval | |||||
| 0-4 | |||||
| Breast Cancer | 2454 | 250 (94.3) | 2204 (48.5) | 39 | 18.3 (10.7-31.3) |
|
Women without
Cancer |
2358 | 15 ( 5.7) | 2343 (51.5) | 27 | 1.0 |
| 5-9: | |||||
| Breast Cancer | 2101 | 56 (70.9) | 2045 (47.3) | 26 | 2.3 (1.4-3.9) |
|
Women without
Cancer |
2301 | 23 (29.1) | 2278 (52.7) | 25 | 1.0 |
|
First Lymphedema Diagnosis By a Health
Professional During Time Interval | |||||
| 10+ | |||||
| Breast Cancer | 1509 | 41 (69.5) | 1468 (46.9) | 17 | 1.9 (1.0-3.4) |
|
Women without
Cancer |
1683 | 18 (30.5) | 1665 (53.1) | 18 | 1.0 |
| First Reported Occurrence of Osteopenia During Time Interval | |||||
| 0-4 : | |||||
| Breast Cancer | 2309 | 309 (70.4) | 2000 (48.5) | 66 | 1.5 (1.2-1.9) |
|
Women without
Cancer |
2251 | 130 (29.6) | 2121 (51.5) | 55 | 1.0 |
| 5-9: | |||||
| Breast Cancer | 1964 | 386 (67.6) | 1578 (45.3) | 63 | 1.6 (1.4-2.0) |
|
Women without
Cancer |
2092 | 185 (32.4) | 1907 (54.7) | 54 | 1.0 |
| First Reported Occurrence of Osteopenia During Time Interval | |||||
| 10+: | |||||
| Breast Cancer | 1176 | 109 (60.9) | 1067 (44.0) | 45 | 1.2 (0.9-1.7) |
| Women without Cancer | 1426 | 70 (39.1) | 1356 (66.0) | 37 | 1.0 |
| First Reported Occurrence of Osteoporosis During Time Interval | |||||
| 0-4 : | |||||
| Breast Cancer | 2382 | 79 (63.7) | 2303 (50.2) | 66 | 1.1 (0.7-1.6) |
| Women without Cancer | 2331 | 45 (36.3) | 2286 (49.8) | 47 | 1.0 |
| 5-9: | |||||
| Breast Cancer | 2256 | 147 (72.7) | 2109 (49.0) | 64 | 1.8 (1.3-2.4) |
| Women without Cancer | 2250 | 55 (27.3) | 2195 (51.0) | 38 | 1.0 |
| First Reported Occurrence of Osteoporosis During Time Interval | |||||
| 10+: | |||||
| Breast Cancer | 1585 | 42 (55.3) | 1543 (49.0) | 50 | 0.8 (0.5-1.2) |
|
Women without
Cancer |
1643 | 34 (44.7) | 1609 (51.0) | 36 | 1.0 |
|
First Reported Occurrence of Myocardial Infarction, Congestive Heart Failure, or
Coronary Heart Disease During Time Interval | |||||
| 0-4 : | |||||
| Breast Cancer | 2497 | 37 (60.7) | 2460 (51.0) | 13 | 1.2 (0.7-2.1) |
| Women without Cancer | 2391 | 24 (39.3) | 2367 (49.0) | 11 | 1.0 |
| 5-9: | |||||
| Breast Cancer | 2410 | 41 (57.8) | 2369 (50.8) | 12 | 0.8 (0.5-1.4) |
| Women without Cancer | 2329 | 30 (42.2) | 2299 (49.2) | 10 | 1.0 |
|
First Reported Occurrence of Myocardial Infarction,
Congestive Heart Failure, or Coronary Heart Disease During Time Interval | |||||
| 10+: | |||||
| Breast Cancer | 1772 | 22 (57.9) | 1750 (50.7) | 9 | 1.1 (0.5-2.2) |
|
Women without
Cancer |
1718 | 16 (42.1) | 1702 (49.3) | 8 | 1.0 |
a
Counts of women under observation at the start of each time interval. Each successive time interval has fewer women under observation, as those who had an event in a previous interval and those who did not have longer follow-up drop out.
b
No women had missing data for time interval
c
Adjusted for age, race, ethnicity, education, and body mass index. Menopausal status, menopausal hormone use and smoking were accounted for as time-dependent covariates: Women were coded as ‘0’ until the age they became exposed, and as “1” for the ages exposed
d
CI - Confidence Interval