Table 1.

Parameters for all continuum calculations

Parameters	Values
Electrostatics grid dimensions	161 x 161 x 161 Å3
Coarse grid lengths	200 x 200 x 200 Å3
Fine grid lengths	50 x 50 x 50 Å3
Radial points	1,400
Counter-ions	0.1 M symmetric salt
Protein dielectric	2.0
Membrane dielectric	2.0
Head group dielectric	80.0
Solvent dielectric	80.0
Solvent probe radius	1.4 Å
Surface sphere density	10.0 grid points/Å2
Temperature	298.15 K
Membrane thickness	See Table 2
Head group thickness	8.0 Å
Bending modulus (Kc)	See Table 2
Compression modulus (Ka)	2.30 x 10-11 N/Å
Surface tension (α)	3.00 x 10—13 NÅ
Outer boundary radius	800 or 19.5 Å