Table 1.
Selected characteristics of study participants by quartile of Lp-PLA2 mass in 3,320 participants of the Cardiovascular Health Study
| Lp-PLA2 Mass (ng/ml) | ||||||
|---|---|---|---|---|---|---|
| < 257.3 | 257.3-326.6 | 326.7-404.8 | ≥ 404.9 | Total | ||
| N | 843 | 857 | 826 | 794 | 3320 | |
|
| ||||||
| Characteristic | N(%) or Mean(SD) |
N(%) or Mean(SD) |
N(%) or Mean(SD) |
N(%) or Mean(SD) |
N(%) or Mean(SD) |
p- value* |
|
| ||||||
| Age (years) | 71.5 (4.6) | 71.8 (4.8) | 71.9 (4.6) | 72.4 (5.1) | 71.9 (4.8) | 0.001 |
| Sex | ||||||
| Female | 550 (65.2) | 540 (63.0) | 455 (55.1) | 423 (53.3) | 1968 (59.3) | <0.001 |
| Male | 293 (34.8) | 317 (37.0) | 371 (44.9) | 371 (46.7) | 1352 (40.7) | |
| Race | ||||||
| Caucasian | 633 (75.1) | 720 (84.0) | 738 (89.3) | 736 (92.7) | 2827 (85.2) | <0.001 |
| Other | 210 (24.9) | 137 (16.0) | 88 (10.7) | 58 (7.3) | 493 (14.8) | |
| Education | ||||||
| LT High School | 173 (20.5) | 195 (22.8) | 192 (23.3) | 234 (29.5) | 794 (24.0) | 0.002 |
| High School/GED | 246 (29.2) | 235 (27.5) | 251 (30.5) | 222 (28.0) | 954 (28.8) | |
| Some College | 203 (24.1) | 211 (24.6) | 203 (24.6) | 178 (22.4) | 795 (24.0) | |
| College/Post | ||||||
| Graduate | 220 (26.1) | 215 (25.1) | 178 (21.6) | 159 (20.1) | 772 (23.3) | |
| Body Mass Index | 26.7 (4.7) | 26.4 (4.4) | 26.8 (4.2) | 26.2 (4.1) | 26.5 (4.4) | 0.02 |
| Diabetes Status** | ||||||
| Normal | 607 (72.1) | 649 (76.1) | 616 (74.8) | 575 (72.5) | 2447 (73.9) | 0.41 |
| IFG | 113 (13.4) | 97 (11.4) | 109 (13.2) | 111 (14.0) | 430 (13.0) | |
| Definite Diabetes | 122 (14.5) | 107 (12.5) | 98 (11.9) | 107 (13.5) | 434 (13.1) | |
| Hypertension Status | ||||||
| Normal | 403 (47.9) | 386 (45.1) | 358 (43.3) | 356 (44.8) | 1503 (45.3) | 0.58 |
| Borderline | 105 (12.5) | 120 (14.0) | 122 (14.8) | 118 (14.9) | 465 (14.0) | |
| Definite | 333 (39.6) | 350 (40.9) | 346 (41.9) | 320 (40.3) | 1349 (40.7) | |
| Smoking Status | ||||||
| Never | 422 (50.2) | 418 (48.8) | 382 (46.2) | 352 (44.4) | 1574 (47.5) | 0.12 |
| Former | 341 (40.5) | 348 (40.6) | 358 (43.3) | 338 (42.6) | 1385 (41.8) | |
| Current | 78 (9.3) | 91 (10.6) | 86 (10.4) | 103 (13.0) | 358 (10.8) | |
|
Alcohol Use (drinks per week) mean |
2.9 (7.3) | 2.6 (6.3) | 2.9 (6.6) | 2.2 (5.3) | 2.6 (6.4) | 0.07 |
|
History of CHD
(Baseline) |
||||||
| No CHD | 718 (85.2) | 724 (84.5) | 686 (83.1) | 657 (82.7) | 2785 (83.9) | 0.49 |
| Prevalent CHD | 125 (14.8) | 133 (15.5) | 140 (16.9) | 137 (17.3) | 535 (16.1) | |
| History of Stroke (Baseline) | ||||||
| Incident | 826 (98.0) | 835 (97.4) | 805 (97.5) | 762 (96.0) | 3228 (97.2) | 0.08 |
| Prevalent | 17 (2.0) | 22 (2.6) | 21 (2.5) | 32 (4.0) | 92 (9.8) | |
|
Common Carotid
IMT (mm) |
1.03 (0.18) | 1.04 (0.20) | 1.05 (0.21) | 1.06 (0.22) | 1.04 (0.20) | 0.03 |
|
Internal Carotid IMT (mm) |
1.32 (0.52) | 1.35 (0.52) | 1.40 (0.54) | 1.45 (0.56) | 1.38 (0.54) | <0.001 |
|
C-Reactive Protein
(mg/L) |
3.34 (6.69) | 3.06 (4.47) | 3.02 (6.52) | 3.19 (5.54) | 3.15 (5.87) | 0.68 |
| Interleukin-6 (pg/ml) | 1.97 (2.28) | 2.08 (1.75) | 1.96 (1.40) | 2.04 (1.41) | 2.01 (1.75) | 0.48 |
| APOE ε4 Allele | ||||||
| No ε4 Allele | 590 (76.6) | 602 (76.2) | 565 (75.7) | 547 (74.8) | 2304 (75.9) | 0.95 |
| 1 ε4 Allele | 171 (22.2) | 177 (22.4) | 173 (23.2) | 172 (23.5) | 693 (22.8) | |
| 2 ε4 Alleles | 9 (1.2) | 11 (1.4) | 8 (1.1) | 12 (1.6) | 40 (1.3) | |
|
Any Lipid Lowering
Drug |
||||||
| No | 777 (92.3) | 808 (94.4) | 786 (95.2) | 770 (97.1) | 3141 (94.7) | <0.001 |
| Yes | 65 (7.7) | 48 (5.6) | 40 (4.8) | 23 (2.9) | 176 (5.3) | |
| Cholesterol (mg/dl) | 200 (36) | 210 (36) | 215 (37) | 222 (42) | 212 (38) | <0.001 |
| LDL (mg/dl) | 118 (32) | 127 (33) | 134 (33) | 142 (37) | 130 (35) | <0.001 |
| Triglyceride (mg/dl) | 131 (66) | 134 (69) | 142 (68) | 137 (69) | 136 (68) | 0.008 |
*
p-values for chi-square tests or analysis of variance are shown for categorical and continuous variables, respectively.