Figure 8. Multiple intrathecal applications of TRPV1 antagonists cumulatively antagonize mechanical allodynia.

A and B, long-term effects of multiple applications of ruthenium red and capsazepine for consecutive 7 days (n = 6). C and D, reconstruction of the decay response diagram from A and B after the withdrawal of RR (A) and CPZ (B) (n = 6).The value in longitudinal axis was normalized by the thresholds value on DMA 20 d. The linear regressions were performed to calculate the decay rates and to evaluate the half decay times (‘Decay₅₀’), and the results are shown above the plots. *P<0.05, **P<0.01 vs. vehicle control of the same time. ^# P<0.05, ^## P<0.01 vs. drugs of middle dose.