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. 2014 Jul 14;9(7):e102327. doi: 10.1371/journal.pone.0102327

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© 2014 Shao et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) Expression difference of TCR-Vβ subfamily between TIL and PBL (Δ value) is calculated as the percentage of each TCR-Vβ subfamily in CD3⁺ TIL minus the counterpart in CD3⁺ PBL. All 24 Δ values (for 24 TCR-Vβ subfamilies) were used to generate a histogram for each patient. The numbers in brackets are the ages of patients. (B) The dispersion degree of Δ values is expressed as variance. The variances were subsequently matched with the age of the patient to generate a scatter plot. (C) The linear correlation coefficient between variance and age was subsequently computed by SPSS software with Spearman's rank-order correlation model.