Table 2.
Trophic Factor and Cytokine Levels in Post-mortem Ventricular Fluid.
| Protein | Control | Alzheimer | P- Value |
|---|---|---|---|
| Trophic Factors | |||
| β-NGF | 41.76 ± 4.26 | 48.60 ± 8.14 | |
| PDGF-AA | 111.52 ± 9.94 | 59.73 ± 4.69 | 0.0002 |
| HGF | 1305.97 ± 299.12 | 3887.81 ± 691.31 | 0.0001 |
| VEGF | 195.74 ± 12.52 | 120.72 ± 9.74 | 0.0003 |
| β-FGF | 948.78 ± 81.77 | 546.07 ± 46.79 | 0.0005 |
| Cytokines | |||
| IL-1β | 123.40 ± 44.97 | 34.23 ± 7.75 | 0.028 |
| IL-6 | 316.64 ± 108.93 | 126.60 ± 91.79 | 0.009 |
| IL-8 | 806.30 ± 321.41 | 929.34 ± 185.10 | |
| IL-10 | 18.20 ± 1.19 | 13.95 ± 0.97 | 0.008 |
| Il-16 | 2769.95 ± 244.39 | 3058.46 ± 219.60 | |
| IL-18 | 365.60 ± 48.50 | 672.60 ± 218.45 | |
| TNF-α | 12.95 ± 1.03 | 15.93 ± 2.72 | |
| TRAIL | 61.14 ± 13.65 | 25.67 ± 2.84 | 0.01 |
| LIF-1 | 58.19 ± 3.02 | 51.27 ± 3.06 | |
| SCF | 30.14 ± 3.14 | 28.14 ± 1.29 | |
| MCP-1 (CCL2) | 1793.48 ± 559.87 | 1123.61 ± 496.75 | 0.001 |
| SDF (CXCL12) | 79.25 ± 11.76 | 29.75 ± 2.76 | <0.0001 |
| GM-CSF | 39.05 ± 1.29 | 33.54 ± 2.83 | |
| MIP-1 | 2279.33 ± 791.99 | 1177.78 ± 142.71 | |
| IFN-γ | 6.66 ± 0.37 | 6.93 ± 0.55 | |
| IP-10 | 734.19 ± 479.61 | 398.13 ± 96.21 |
Postmortem ventricular fluid samples from aged controls or patients with documented late-stage AD (N=10/group) were used to measure immunoreactivity to trophic factors by direct binding ELISAs, and cytokines by multiplex bead-based ELISAs. Immunoreactivity was normalized to protein concentration and data are expressed as mean ± SEM of fluorescence light units (arbitrary). Inter-group comparisons were made with the Student T-test. Significant P values are listed in the right column.