Table 3.
CSF Trophic Factor and Cytokine Levels in Probable AD.
| Protein | Control | Alzheimer | P- Value |
|---|---|---|---|
| Trophic Factors | |||
| β-NGF | 5.69 ± 0.77 | 4.68 ± 0.17 | P=0.10 |
| PDGF | 19.88 ±1.27 | 19.19 ± 0.36 | |
| HGF | 98.00 ± 7.09 | 111.5 ± 10.44 | |
| VEGF | 89.00 ± 2.15 | 103.9 ± 2.45 | P<0.0001 |
| β-FGF | 89.81 ± 2.50 | 81.81 ± 2.29 | P=0.025 |
| Cytokines | |||
| IL-1β | 6.25 ± 0.62 | 4.69 ± 0.17 | P=0.018 |
| IL-6 | 21.00 ± 3.05 | 31.19 ± 4.42 | P=0.067 |
| IL-8 | 68.25 ± 8.50 | 77.00 ± 7.70 | |
| IL-10 | 10.81 ± 0.51 | 11.50 ± 0.43 | |
| Il-16 | 14.75 ± 0.71 | 17.44 ± 0.59 | P=0.0035 |
| IL-18 | 11.81 ± 1.98 | 8.94 ± 0.83 | P=0.095 |
| TNF-α | 7.31 ± 0.66 | 6.38 ± 0.26 | 0.098 |
| TRAIL | 14.94 ± 1.05 | 14.13 ± 0.39 | |
| LIF | 36.56 ± 1.82 | 41.56 ± 1.34 | P=0.017 |
| SCF | 57.63 ± 6.13 | 64.0 ± 5.08 | |
| MCP-1 (CCL2) | 2971 ± 80.11 | 3165 ± 118.3 | P=0.093 |
| SDF (CXCL12) | 21.88 ± 2.11 | 22.06 ± 1.51 | |
| GM-CSF | 28.38 ± 1.27 | 29.00 ± 0.71 | |
| MIP-1β | 85.94 ± 10.94 | 98.13 ± 6.90 | |
| IFN-γ | 3.75 ± 0.62 | 3.00 ± 0.05 | |
| IP-10 | 1578 ± 155.9 | 1739 ± 121.0 |
CSF samples from controls (N=12) or patients with clinically diagnosed probable AD (N=16; confirmed by postmortem exam) were used to measure immunoreactivity to trophic factors by direct binding ELISAs, and cytokines by multiplex bead-based ELISAs. Immunoreactivity was normalized to protein concentration and data are expressed as mean ± SEM of fluorescence light units (arbitrary). Inter-group comparisons were made with the Student T-test. Significant P values are listed in the right column.