Table 3.
Anterior cingulate cortical (ACC) volumes and white matter tract fractional anisotropy (FA) in depressed and normal elders
| Variable | Depressed (N=45) Mean (SD) | Normal elders (N=43) Mean (SD) | P-value |
|---|---|---|---|
| Grey matter volumes | |||
| Dorsal ACC, left | 2.52 (0.50) | 4.11 (1.15) | 0.00** |
| Dorsal ACC, right | 2.60 (0.66) | 4.39 (0.95) | 0.00** |
| Rostral ACC, left | 1.98 (0.67) | 3.09 (1.20) | 0.00** |
| Rostral ACC, right | 1.90 (0.65) | 2.47 (1.12) | 0.04* |
| Anterior subgenual, left | 0.73 (0.23) | 0.74 (0.24) | 0.79 |
| Anterior subgenual, right | 0.74 (0.24) | 0.74 (0.19) | 0.79 |
| Posterior subgenual, left | 0.53 (0.15) | 0.58 (0.20) | 0.16 |
| Posterior subgenual, right | 0.53 (0.17) | 0.58 (0.20) | 0.12 |
| White Matter FA | |||
| Uncinate fasciculus, left | 0.36 (0.04) | 0.38 (0.05) | 0.06 |
| Uncinate fasciculus, right | 0.35 (0.04) | 0.37 (0.05) | 0.07 |
| Corpus callosum, total | 0.44 (0.05) | 0.44 (0.05) | 0.93 |
| Corpus callosum, genu | 0.51 (0.07) | 0.52 (0.05) | 0.34 |
| Corpus callosum, splenium | 0.61 (0.08) | 0.64 (0.07) | 0.04* |
| Superior corona radiata, left | 0.43 (0.04) | 0.42 (0.05) | 0.08 |
| Superior corona radiata, right | 0.41 (0.04) | 0.40 (0.04) | 0.07 |
| Anterior corona radiata, left | 0.32 (0.05) | 0.33 (0.05) | 0.25 |
| Anterior corona radiata, right | 0.31 (0.06) | 0.31 (0.05) | 0.28 |
| Superior longitudinal fasciculus, left | 0.38 (0.04) | 0.39 (0.05) | 0.26 |
| Superior longitudinal fasciculus, right | 0.37 (0.04) | 0.38 (0.04) | 0.16 |
| Inferior longitudinal fasciculus, left | 0.40 (0.06) | 0.41 (0.04) | 0.38 |
| Inferior longitudinal fasciculus, right | 0.40 (0.06) | 0.41 (0.04) | 0.18 |
| Centrum semiovale, left | 0.40 (0.07) | 0.40 (0.04) | 0.83 |
| Centrum semiovale, right | 0.38 (0.04) | 0.38 (0.05) | 0.58 |
Unadjusted mean grey matter volumes are presented in cm3. Mann Whitney U comparisons:
*
Depressed vs. Normal elders p<.05
**
Depressed vs. Normal elders p<.01