Skip to main content
. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: J Biol Chem. 2005 Jul 20;280(37):32230–32237. doi: 10.1074/jbc.M504553200

FIGURE 4. Inhibitory effect of the SOC blocker nickel chloride on CCE amplitude.

FIGURE 4

A, during exposure to Ca2+-free medium containing 0.5 mm EGTA, ICS depletion resulted from addition of 10 μm CPA to the bathing medium. Following emptying of ICS calcium content, calcium add-back (1 mm) elicited a rise in calcium. Such an increase decreased with nickel chloride (0.5 mm), resulting from inhibition of SOC activation (n = 5). Washout of nickel chloride-containing solution failed to restore the F340 nm/F380 nm ratio to its pre-inhibited level. B, summary of results from five different cells.