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. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: J Biol Chem. 2005 Jul 20;280(37):32230–32237. doi: 10.1074/jbc.M504553200

FIGURE 7. EGF-induced SOC activation is dependent on TRPC4 protein expression.

FIGURE 7

A, currents after establishing the whole cell configuration (upper panel) and EGF (20 ng/ml)-induced increases in SOC inward currents (lower panel). B, I-V plot. After breaking into the whole cell configuration (○), a significant increase in EGF-induced SOC currents was observed in non-transfected HCEC (20 ng/ml EGF; n = 4; p < 0.005). C, no significant increases in currents observed in either the absence (upper panel) or presence (lower panel) of 20 ng/ml EGF in TRPC4 siRNA-transfected HCEC. D, I-V plot revealing that EGF-induced increases in SOC currents were suppressed in TRPC4 siRNA-transfected HCEC (n = 4; p > 0.64).