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Optimal discrimination values for VC and VD variants
| Index test | Optimal cutoff value |
Optimal Youden index |
Corresponding sensitivity (95% CI) |
Corresponding specificity (95% CI) |
|---|---|---|---|---|
| Normalized VC | 4.2 | 0.9 | 1.0 (0.85, 1.00) | 0.9 (0.78, 0.96) |
| Normalized VD | 2.9 | 0.9 | 1.0 (0.85, 1.00) | 0.9 (0.78, 0.96) |
| LVEF ≤ 20% | 4.5 | 0.1 | 0.6 (0.41, 0.79) | 0.5 (0.35, 0.64) |
LVEF, Left ventricular ejection fraction; VC, SCN5A variant C; VD, SCN5A variant D
