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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Clin Cancer Res. 2014 Mar 25;20(11):2873–2884. doi: 10.1158/1078-0432.CCR-14-0205

Figure 1.

Figure 1

Next generation sequencing analysis of MOC cell lines (A) Overview of MOC cell line model illustrating biologic behavior upon flank injection of cells. Note MOC23 (italicized) only grows in RAG2−/− mice, (B) Number of SNVs in each MOC line, (C) Distribution of DMBA induced changes in 6 core driver pathways of HNSCC shown as a “signal flag” plot of mutation subtypes in the indolent and aggressive cell lines (numbers of genes in each driver pathway in parentheses). The boxed nucleotide changes (A→T, T→A, C→A and G→T) represent the most common DMBA induced alterations. Note, the underlined G:C→T:A change is typical for tobacco-induced mutations (11). (D) Selected Oncoprint of mutation rates within the TCGA cohort for AKAP proteins showing that 57/279 patients have alterations in indicated AKAPs. (E) Oncoprint for MED proteins showing that 41/279 patients have alterations in indicated MED components.