Table 1. Cases of osseous blastomycosis without evidence of pulmonary or systemic involvement.

Patient (yrs/sex)	Site	Symptoms	Symptom Durationa (mo)	Diagnosis	Specimen	WBC (k/μL)	ESR (mm/h)	CXR	Location/ Occupation	Therapy (dose)	Therapy Duration (mo)	Ref.
49/M	Right ankle	Ankle pain, swelling & drainage	5	Culture	Ankle tissue & bone	7.7	8	Normal	Virginia/sprinkler fitter	Posaconazole (400mg twice daily)	6	This report
3/UKN	Left femur	Left knee pain	UKN	Pathology	Purulent fluid adjacent to femur	Normal	N/Db	N/Dc	Ghana & Italy/N/A	Lipid Amphotericin B (0.7mg/kg/day); Itraconazole (10mg/kg/day)	6	Codifava et al 2012
17/F	T12-L2	Back & left leg pain	15	Culture	Aspiration left psoas fluid	5.6	57	Normal	Alabama or Arkansas/UKN	Itraconazole (200mg twice daily)	6	Saccente et al 1998
29/M	Right knee	Knee pain & swelling	12	Culture	Patellar tissue	5	N/D	Normal	Nebraska/agronomist	Itraconazole (100mg twice daily)	12	Veligandla et al 2002
36/M	Right knee	Knee pain	1	Culture	Granulation tissue	8	N/D	N/Dd	Nebraska/welder	Itraconazole (200mg daily)	12	Veligandla et al 2002
24/F	Left temporal	Headache & otitis	12+	Pathology	Tympanic membrane	13	30	Normal	Tennessee & Florida/UKN	Amphotericin B (total dose of 2.5g)	5	Farr et al 1992
40/M	Left mandible	Mandibular swelling & pain	3	Culture	Sinus tract drainage	10	84	Normal	Wisconsin/UKN	Ketoconazole (200mg daily)	26	Wagner et al 1985

^aDuration of illness before diagnosis of osseous blastomycosis,

^bC-Reactive Protein 13.22 mg/dl,

^cTotal body CT was negative,

^d“No abnormalities noted on the pulmonary examination” (Veligandla et al 2002)

WBC = White Blood Cell, ESR = Erythrocyte Sedimentation Rate, CXR = Chest X-ray, UKN = Unknown, N/D = Not Done, N/A = Not Applicable