Treatment with 5.0% CBD gel resulted in a reduction in Fluoro-Jade B positive (FJB+) cells in the entorhinal cortex following binge ethanol treatment. Quantification of FJB+ cells in the entorhinal cortex (A). Control rats typically had < 1 FJB+ cell/section therefore were collapsed across treatment groups. Additionally, ethanol and ethanol + vehicle treated rats were indistinguishable, therefore collapsed. Representative images for each treatment group (B): control, i; ethanol, ii; ethanol + vehicle, iii; ethanol + 1.0% CBD, iv; ethanol + 2.5% CBD, v; ethanol + 5.0% CBD, vi. Scale bars = 50 μm.