Figure 6.
Treatment with CBD by either IP injection or a second generation transdermal CBD gel resulted in a reduction in Fluoro-Jade B positive (FJB+) cells in the entorhinal cortex following binge ethanol treatment. Quantification of FJB+ cells in the entorhinal cortex (A). Control rats typically had < 1 FJB+ cell/section therefore were collapsed across treatment groups. Representative images for each treatment group (B). control, i; ethanol, ii; ethanol + VEH IP, iii; ethanol + VEH gel, iv; ethanol + 2.5% CBD gel, v; ethanol + CBD IP, vi. *, p < 0.05 compared to ethanol. Scale bars = 50 μm.