Table 3.

Substrate peptides differentially phosphorylated between schizophrenia and comparison subjects in the kinome array.

Increased Signal	Uniprot Accession	Abbreviation	Fold Change	Upstream kinase pathway
G-protein signaling modulator 2	P81274	GPSM2	1.329	PKC
Phosphorylase b kinase alpha M subunit	P46020	PHKA1	1.295	PIM1; PKA
Cystic fibrosis transmembrane conductance regulator	P13569	CFTR	1.263	PIM1
β-2 adrenergic receptor	P07550	ADRB2	1.250	MSK; CAMKIV; PKA
cAMP-responsive element-binding protein	P16220	CREB1	1.221	PIM1; MSK; PKC
Macrophage colony-stimulating factor 1 receptor	P07333	CSF1R	1.217	PIM1
Annexin 1	P04083	ANXA1	1.204	NPR1; PKG2
Vasodilator-stimulated phosphoprotein	P50552	VASP	1.192	MSK; PKG1
Erythrocyte protein 4.2	P16452	EPB42	1.185	PIM1; PKC
Protein tyrosine kinase 6	Q13882	PTK6	1.180	PKC; AKT; PIM3
G-protein coupled receptor 6	P46095	GPR6	1.164	p38 MAPK; ERK1
Phospholemman ion transport regulator	O00168	FXYD1	1.156	PKC; PIM1
Proto-oncogene c-Rel	Q04864	REL	1.152	PIM1; PKG
Vitronectin adhesion molecule	P04004	VTN	1.152	PKA; PKC; RSK
Decreased Signal	Uniprot Accession	Abbreviation	Fold Change	Upstream Kinase Pathway
Ets-domain containing protein	P19419	ELK1	-1.446	ERK1/2; p38; JNK
Myelin basic protein	P02686	MBP	-1.300	mTOR; JNK; ERK1/2
E3 ubiquitin ligase	P22681	CBL	-1.277	CHEK1; PKC; JNK; GSK3B
Serine/threonine protein kinase 2	O96017	CHEK2	-1.242	PIM1; CHEK2; MEK; PDK1; JNK
Tyrosine protein kinase	P43403	ZAP70	-1.173	mTOR; CDK4

14 peptides exhibited a 1.15-fold or more increase in kinase activity while 5 exhibited a 1.15-fold or more decrease in phosphorylation.