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. Author manuscript; available in PMC: 2015 Jun 3.
Published in final edited form as: Brain Res. 2014 Apr 26;1568:42–54. doi: 10.1016/j.brainres.2014.04.029

Table 4.

Ingenuity Pathway Analysis of the schizophrenia kinome

Molecular and Cellular Functions IPA p-value # Molecules Function Annotation (# molecules)
Cellular Function and Maintenance 7.09E-11–5.85E-3 16 Cellular homeostasis (14); Cytoskeletal organization (10); Microtubule dynamics (7); Ion homeostasis (8); Ca2+ flux (6); T cell development (7)
Cellular Movement 8.97E-8–6.23E-3 13 Leukocyte migration (9); Migration of cells (11); invasion of cells (7); cell movement of myeloid cells (6)
Molecular Transport 1.16E-9–5.85E-3 10 Ion flux (7); Flux of Ca2+ (6); influx of Ca2+ (5); mobilization of Ca2+ (5); uptake of D-glucose (4)
Cell Development 1.85E-7–4.92E-3 14 Development of leukocytes (8); Proliferation of blood cells (9); Differentiation of cells (12)
Cellular Growth and Proliferation 3.03E-7–6.03E-3 15 Proliferation of blood cells (9); Proliferation of monocytes (8); Proliferation of T lymphocytes (7)
Physiological Systems and Development IPA p-value # Molecules Physiological System Annotation
Hematological System and Development 1.85E-7-5.9E-3 14 Leukocyte development (8); T-cell development (7); proliferation of monocytes (8)
Hematopoeisis 1.85E-7-5.85E-3 10 Leukocyte development (8); T-cell development (7); proliferation of monocytes (8)
Lymphoid Tissue Structure and Development 1.85E-7-4.23E-3 11 Leukocyte development (8); T-cell development (7); Differentiation of T lymphocytes (5)
Immune Cell Trafficking 5.35E-7-5.9E-3 10 Leukocyte migration (9); Cell movement of leukocytes (8) Cell movement of myeloid cells (6)
Top Canonical Pathways IPA p-value Downstream Pathways
FLT3 Signaling in Hematopoietic Progenitor Cells 5.11E-5 PI3K-Akt; Ras-MEK-ERK; JAK-STAT
Glucocorticoid Receptor Signaling 1.15E-4 PI3K-Akt; Ras-MEK-ERK; GSK3β; NFκB; SGK
T Cell Receptor Signaling 1.28E-4 PI3K-Akt-NFκB; Ras-MEK-ERK; p38; PKCθ-JNK
Gαs signaling 1.87E-4 PKA; Ras-MEK-MAPK
PI3K signaling in B Lymphocytes 2.8E-4 AKT-GSK3β; AKT-NFκB

Molecular and cellular functions, physiological and developmental functions, and canonical pathways determined by IPA to correspond to the differentially activated kinases in the kinome array data set.