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. Author manuscript; available in PMC: 2014 Nov 2.
Published in final edited form as: Science. 2014 Apr 10;344(6183):1252304. doi: 10.1126/science.1252304

Fig. 4. Neuronal activity initiates differentiation.

Fig. 4

(A) Total number of EdU+ cells in Thy1::ChR2 and WT mice at 24 hours (n = 4 per group) and 4 weeks (n = 7 per group) poststimulation. (B to D) Representative confocal micrographs illustrating colocalization of EdU (red) with markers (green) of cell mitosis (Ki67), apoptosis (cleaved caspase-3), or histone modification markers histone H3 lysine 9 trimethylation (H3K9me3) and histone H3 acetylation (AcH3). In all graphs, red bars indicate Thy1::ChR2 mice; blue bars denote identically manipulated WT littermate controls. *P < 0.05, **P < 0.01,***P < 0.001. n.s. denotes P > 0.05. Error bars indicate SEM. Scale bars, 10 mm. Value of (—) over x axis = 0 ± 0.