Table 3.
Biomarker levels across PGF status and logistic regression models for the association of cord blood VEGF and sFlt-1 on the development of PGF.
| Biomarker pg/ml median (IQR) | OR (95% CI) | ||||
|---|---|---|---|---|---|
| Non-PGF | PGF | Model 1 | Model 2 | Model 3 | |
| VEGF | 89.7 (37.8, 221.9) | 49.0 (32.3, 104.3) | 0.7 (0.5, 0.9)* | 0.6 (0.4, 0.9)* | 0.6 (0.4, 0.9)* |
| sFlt-1 | 451.3 (269.1, 862.0) | 798.7 (327.5, 1384.1) | 1.6 (1.1, 2.4)* | 1.3 (0.8, 2.1) | 1.4 (0.8, 2.2) |
| Stratified by placental vascular pathology (none versus any)** | |||||
| VEGF | |||||
| No vascular pathology | 64.9 (34.9, 349.3) | 58.6 (29.3, 214.0) | 0.8 (0.5, 1.4) | ||
| Any vascular pathology | 95.4 (58.0, 175.8) | 48.5 ** (35.8, 87.1) | 0.5 (0.3, 1.1) | ||
| sFlt-1 | |||||
| No vascular pathology | 398.6 (205.2, 738.8) | 515.0 (296.0, 809.9) | 1.3 (0.6, 2.8) | ||
| Any vascular pathology | 615.0 (330.9, 1121) | 1028 (417.9, 1829.3) | 1.5 (0.8, 2.7) | ||
P<0.05. Odds ratios (OR) and 95% confidence intervals (CI) calculated using logistic regression. Model 1: adjusted for maternal race, infant gender, multiple gestation, and gestational age at birth. Model 2: further adjusted for maternal preeclampsia and small-for-gestational age birth weight (<10th percentile). Model 3: further adjusted for bronchopulmonary dysplasia, necrotizing enterocolitis, intraventricular hemorrhage, and retinopathy of prematurity.
Stratified models adjusted according to Model 1, and include patients with complete placental histopathology data (N=98). P<0.05 for PGF vs. Non-PGF among infants with placental vascular pathology.