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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Curr Opin Cardiol. 2014 May;29(3):199–206. doi: 10.1097/HCO.0000000000000054

Figure 2. LncRNAs in vascular diseases.

Figure 2

A) ANRIL, also known as CDKN2B-AS (antisense) transcript recruits PRC complex in cis and regulates the transcriptional repression of CDKN2A and CDKN2B. Single nucleotide variants within the ANRIL locus are associated with many diseases including coronary artery disease. B) Lnc-Ang362 locus, marked by H3K4me3 at the transcriptional start site and H3K36me3 through the gene body in vascular smooth muscle cells (nucleosomes highlighted with red and light blue, respectively, encodes an Angiotensin II (Ang II) regulated lncRNA. Lnc-Ang362 RNA is the host transcript for two miRNAs, miR-221 and miR-222 which regulate VSMC proliferation, and ultimately mediates the response to Ang II.