Figure 10. A summary scheme for the effect of Rb-controlled redox on cell fate.

Different redox states in 3T3 cells determine the corresponding biological activities. Over-oxidation, a redox state more reductive than the baseline of 3T3/wt (Rb^+/+) cells; over-reduction, a redox state more oxidative than the level in 3T3/Rb^−/− cells. Over-oxidative and reductive states are beyond the regulation ability of Rb and finally induce cell death. Rb regulates cell survival or transformation by controlling redox homeostasis.