Table 2.
Predictors of time to cardiovascular event, using multivariate Cox regression.
| Variable | HR (95% CI) | p |
|---|---|---|
| MTHFR A1298C* (rs1801131) | ||
| AA | ref | |
| AC | 0.77 (0.49, 1.21) | 0.262 |
| CC | 0.67 (0.33, 1.34) | 0.259 |
| MTHFR C677T* (rs1801133) | ||
| CC | ref | |
| CT | 1.16 (0.74, 1.80) | 0.523 |
| TT | 0.24 (0.06, 1.02) | 0.053 |
| Methotrexate use | 0.66 (0.44, 1.00) | 0.048 |
| Modified Charlson-Deyo index | 1.23 (1.13, 1.34) | < 0.0001 |
| Prior myocardial infarction | 1.70 (1.06, 2.71) | 0.027 |
| Hyperlipidemia | 1.57 (1.01, 2.43) | 0.046 |
| Prior stroke | 2.01 (1.03, 3.90) | 0.040 |
| Education | 0.87 (0.80, 0.95) | 0.003 |
| Smoking status | ||
| Never | ref | |
| Former | 0.92 (0.51, 1.69) | 0.796 |
| Current | 1.29 (0.68, 2.47) | 0.437 |
*
Polymorphisms are listed in order of major allele homozygous, heterozygous, minor allele homozygous. MTHFR: methylenetetrahydrofolate reductase; ref: referent.