TABLE II.

Lung collectin genetic polymorphisms and association with disease

Polymorphism				Clinical association	References
SP-A1 allele	Val19Ala	Val50Leu	Arg219Trp
6A	Ala	Leu	Arg
6A2	Val	Val	Arg	Lower incidence of otitis   media in childhood	Ramet et al, 200163
				Increased risk of RDS in   preterm infants	Haataja et al, 2002253
6A3	Val	Leu	Arg	Reduced risk of RDS in   preterm infants	Haataja et al, 2002253
6A4	Val	Leu	Trp	Increased incidence of   otitis media in   childhood	Ramet et al, 200163
				Increased susceptibility to   tuberculosis	Haataja et al, 2002253
				Increased levels in   patients with idiopathic   pulmonary fibrosis	Selman et al, 2003259
SP-A2 allele	Asn9Thr	Ala91Pro	Gln223Lys
1A	Thr	Pro	Gln	Increased incidence of   ABPA	Saxena et al, 2003174
				Increased susceptibility to   tuberculosis	Madan et al, 2002258
				Reduced severity of RSV   infection in infants	Lofgren et al, 2002256
1A0	Asn	Ala	Gln	Reduced risk of otitis   media in childhood	Ramet et al, 200163
				Increased risk or RDS in   preterm infants	Haataja et al, 2002253
1A1	Thr	Ala	Lys	Increased severity of RSV   infection in infants	Lofgren et al, 2002256
				Increased susceptibility to   N meningitides	Jack et al, 2006257
1A2	Thr	Ala	Gln
1A3	Asn	Ala	Lys	Increased susceptibility to   tuberculosis	Haataja et al, 2002253
				Increased severity of RSV   infection	Haataja et al, 2002253
SP-D single nucleotide   polymorphism	Met11Thr
	Met			Higher SP-D levels	Leth-Larsen et al, 2005261
				Increased incidence of   RSV infection	Lahti et al, 2002260
				Increased incidence of   allergic sensitization	Brandt et al, 2008235
	Thr			Lower SP-D levels;   monomers only	Leth-Larsen et al, 2005261
				Lower incidence of RSV   infection	Lahti et al, 2002260
				Increased susceptibility to   tuberculosis	Floros et al, 2000262
				Decreased incidence of   allergic sensitization	Brandt et al, 2008235

RDS, Respiratory distress syndrome.